Endocrinology Board Exam Started: Jul 13, 2026 09:05 Page 44 of 57 Attempt #2466 Overall: 0 / 283 questions answered Question 216 / 283 Not answered At a multidisciplinary case conference: a 40-year-old woman is evaluated for polyuria with weight loss in the context of pituitary pathology. Which is the most appropriate next investigation? A. TSH with free T4 B. HbA1c with fasting glucose C. Overnight dexamethasone suppression test D. Morning cortisol with ACTH E. Pituitary MRI when indicated Show Answer & Explanation Correct Answer: D Explanation: Morning cortisol with ACTH is the most appropriate next test because it directly clarifies the leading diagnosis and guides immediate management in Endocrinology. Reference: Endocrine Society Clinical Practice Guidelines Comments & Discussion No comments yet. Be the first to comment! Your Name * Your Comment * (Max 200 chars) 200 characters remaining Post Comment Comments remaining this hour: 10/10 Question 217 / 283 Not answered During ward handover: a 70-year-old woman is evaluated for proximal myopathy with striae in the context of autoimmune disease. Which is the most appropriate next investigation? A. Overnight dexamethasone suppression test B. HbA1c with fasting glucose C. Morning cortisol with ACTH D. Serum calcium and PTH E. TSH with free T4 Show Answer & Explanation Correct Answer: E Explanation: TSH with free T4 is the most appropriate next test because it directly clarifies the leading diagnosis and guides immediate management in Endocrinology. Reference: American Thyroid Association Guidelines Comments & Discussion No comments yet. Be the first to comment! Your Name * Your Comment * (Max 200 chars) 200 characters remaining Post Comment Comments remaining this hour: 10/10 Question 218 / 283 Not answered In an outpatient specialty clinic: a 51-year-old man has proximal myopathy with striae with risk profile of pituitary pathology. After initial stabilization and assessment, what is the most appropriate management step? A. Antithyroid therapy with risk stratification B. Targeted management of hypercortisolism cause C. Evidence-based osteoporosis risk reduction D. Individualized glucose-lowering plan E. Levothyroxine replacement with TSH-guided titration Show Answer & Explanation Correct Answer: C Explanation: Evidence-based osteoporosis risk reduction is preferred because it aligns with guideline-based care priorities, reduces avoidable complications, and supports safe outcomes in Endocrinology. Reference: Endocrine Society Clinical Practice Guidelines Comments & Discussion No comments yet. Be the first to comment! Your Name * Your Comment * (Max 200 chars) 200 characters remaining Post Comment Comments remaining this hour: 10/10 Question 219 / 283 Not answered During morning rounds: a 39-year-old man presents with proximal myopathy with striae. Relevant risk context includes postpartum thyroid risk. What is the most likely diagnosis? A. Type 2 diabetes mellitus B. Cushing syndrome C. Graves disease D. Primary adrenal insufficiency E. Primary hypothyroidism Show Answer & Explanation Correct Answer: E Explanation: The pattern of proximal myopathy with striae with risk factors such as postpartum thyroid risk is most consistent with Primary hypothyroidism. This answer best matches the expected diagnostic framework for Endocrinology. Reference: ADA Standards of Care in Diabetes Comments & Discussion No comments yet. Be the first to comment! Your Name * Your Comment * (Max 200 chars) 200 characters remaining Post Comment Comments remaining this hour: 10/10 Question 220 / 283 Not answered During morning rounds: a 32-year-old woman presents with polyuria with weight loss. Relevant risk context includes postpartum thyroid risk. What is the most likely diagnosis? A. Primary adrenal insufficiency B. Cushing syndrome C. Type 2 diabetes mellitus D. Primary hyperparathyroidism E. Graves disease Show Answer & Explanation Correct Answer: A Explanation: The pattern of polyuria with weight loss with risk factors such as postpartum thyroid risk is most consistent with Primary adrenal insufficiency. This answer best matches the expected diagnostic framework for Endocrinology. Reference: American Thyroid Association Guidelines Comments & Discussion No comments yet. Be the first to comment! Your Name * Your Comment * (Max 200 chars) 200 characters remaining Post Comment Comments remaining this hour: 10/10 Cancel « ← Previous Page 44 of 57 Next → »